Google Chrome does render fonts with subpixel anti-aliasing but the text looks more jaggy than in other browsers, because it only supports horizontal anti-aliasing.
The jaggies are specially visible on the top and bottom of the curved letters, like S, O and C, while looking fine on the sides of these letters.
Look at the screenshots of some letters with the Georgia font at 48px:
Can you notice the jaggies on the top of the letters in Chrome?
But after a certain font size, Chrome does some other method to render fonts. In Georgia font, that size is 49px:
The letters are no longer jagged!
If we take a closer look, we can see that while it does look better, it’s not using sub-pixel rendering, but monochromatic anti-aliasing for both the vertical and horizontal directions.
Here’s a closer look at the fonts rendered above, amplified at 500%:
Conclusion: for now if you’re using a big font-size for headers or page titles, consider
font-size: 49px to get the smooth edges on Chrome, at least until they use subpixel for horizontal + monochrome for vertical anti-aliasing like the other browsers.
More information about font rendering:
For browser comparison, here’s how the same text is rendered in Chrome 18 beta, Firefox 11.0 and Internet Explorer 9:
ant the close-ups: